ea0020p187 | Endocrine tumours and neoplasia | ECE2009
Quintero Ana
, Martinez-Fuentes Antonio J
, Dieguez Carlos
, Benito-Lopez Pedro
, Leal Alfonso
, Webb Susan
, Malagon Maria M
, Luque Raul M
, Castano Justo P
Ghrelin was isolated from stomach by its ability to stimulate growth hormone (GH) release through the GH-secretagogue receptor (GHS-R1a). However, ghrelin/GHS-R expression in multiple tissues and tumor types suggested additional roles for this tandem. Ghrelin, a 28-aminoacid peptide, requires a unique O-acylation at its Ser-3 residue to bind GHS-R1a and release GH. Conversely, unacylated ghrelin (UAG), initially considered inactive, seems to play distinct metabolic role...